中文：磷脂-聚乙二醇-马来酰亚胺（MW：5000）
英文：DSPE-PEG-MAL，Maleimide-PEG-DSPE
CAS：474922-22-0
所属分类：DSPE PEG Maleimide PEG
分子量：5k，其他分子量可以定制（10k、2k、1k、3.4k、20k等）
质量控制：95%+。储藏于-20℃长期保存，惰性气体保护避光、干燥。为了达到理想使用效果，材料应始终保持在干燥的低温条件下。避免频繁解冻和冻结。溶于常规溶液及大多数有机溶剂，较少溶于醇、甲苯，不溶于乙醚。现配现用，取用后充入惰性气体，及时放入冰箱。仅供科研实验使用。
DSPE - PEG - MAL is one of the reactive phospholipids PEG reagent, and the hydrophobic (mercaptan, SH) reaction, DSPE (1, 2-2 stearic acyl - sn - glycerol 3 - ethanolamine phosphate) is a kind of highly hydrophobic 18 c saturated phospholipids. On the other hand, PEG (polyethylene glycol) joint has good hydrophilicity and water-soluble, maleic imide faculties of DSPE PEG of derived from a variety of molecular hydrophobic base/thiol groups have excellent reactivity, maleic imide and thiol reaction between easier for under neutral pH.
Maleic imide PEG DSPE liposome is liposome and other lipid nanoparticles on the surface of the antibody, peptides or other ligand spatialization of one of the most commonly used the reactivity of phospholipids. Polyethylene glycol (PEG) of phospholipids have longer cycle time of blood and to the higher stability of the encapsulated drug, this product has high purity, all kinds of molecular weight and chemical reactivity of mercaptan reactive maleic imide phospholipids PEG products integrated products. The lipid PEG conjugated content have excellent amphiphilic, for preparation and transmission of small molecules and macromolecular drugs provide advantages.
磷脂PEG马来酰亚胺（DSPE-PEG-Mal）可以用来修饰蛋白质、多肽以及其他含有巯基的材料或者小分子，马来酰亚胺和巯基在PH6.5-7.5很容易形成稳定的硫醚键，(DSPE)共轭聚乙二醇是磷脂和聚乙二醇结合具有亲水性和疏水性。聚乙二醇磷脂脂质体形成优质材料,可用于药物输送、基因转染和疫苗传递，聚乙二醇化磷脂能显著改善血液循环时间和稳定封装药物，这些材料还可用于靶向给药通过修改与目标表面配体如抗体、多肽。
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